Panel one: stick figures are fine, as long as the format is preserved context clues will let people know what you are doing.

Panel two: we can't deviate too far from the original or it stops being the same meme.

Panel three: variation on the idea is the point of a meme, the name intentionally paralleled genes.

Panel four: That original context is all but lost to most further proving my point.

Panel five: how is this self referential humor recognizable then?

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